Keith M. Vogt, MD, PhD

  • Assistant Professor, Department of Anesthesiology and Perioperative Medicine

I am a practicing anesthesiologist and physician-scientist. My research themes heavy leverage my background as an engineer.  After earning a bachelor’s degree in electrical engineering I received my PhD in Biomedical Engineering from The Ohio State University, with dissertation focused on novel quantitative analysis of functional MRI data.  I have since expanded my own project umbrella to include functional connectivity analyses and multi-voxel pattern activation.  This neuroscience work has predominantly focused on understanding cognitive processes that characterize consciousness, including memory formation and the experience of pain.  I also collaborate on projects that employ machine learning of neuroimaging and electronic health record data to predict and minimize the risk of adverse events in the perioperative period.

Representative Publications

  1. Vogt KM, Ibinson JW, Smith CT, Citro AT, Norton CM, Karim HT, Popov V, Mahajan A, Aizenstein HJ, Reder LM, Fiez JA.  Midazolam and ketamine produce distinct neural changes in memory, pain, and fear networks during pain.  Anesthesiol. 2021, accepted, in-press.
  2. Vogt KM, Norton CM, Speer LE, Tremel JJ, Ibinson JW, Reder LM, Fiez JA. Memory for non-painful auditory items is influenced by whether they are experienced in a context involving painful electrical stimulation. Expr Brain Research. 2019, 237:1615-1627. PMID: 30941440.
  3. Schnetz MP, Hochheiser HS, Danks DJ, Landsittel DP, Vogt KM, Ibinson JW, Whitehurst SL, McDermott SP, Duque MG, Kaynar AM. The triple variable index combines information generated over time from common monitoring variables to identify patients expressing distinct patterns of intraoperative physiology. BMC Med Res Methodol. 2019 Jan 14;19(1):17. PMCID: PMC6332613.
  4. Vogt KM, Becker CJ, Wasan A, Ibinson JW. Human Posterior Insula Functional Connectivity differs between Electrical Pain and the Resting State. Brain Connect 2016, 6:786-794. PMID: 27527402.
  5. Ibinson JW, Vogt KM, Taylor K, Dua S, Becker CJ, Loggia M, Wasan A. Optimizing and Interpreting Functional Connectivity Maps Obtained During Acute Experimental Pain: The effects of global signal and task-paradigm regression. Brain Connect. 2015, 5:649-657. PMID: 26061382.

Research Interests

- Functional magnetic resonance imaging
- Pain processing
- Memory under anesthesia
- Delirium and disorders of consciousness
- Perioperative outcomes

Research Grants

Current Research Support:
Patient Oriented Career Development Award, Vogt (PI)                   7/2019 – 8/2023
NIGMS 1K23GM132755-01A1 
Title: Anesthetic modulation of human memory during acute pain
Goals: Determine the degree to which explicit and implicit memories are formed while experiencing pain during minimal sedation with propofol, dexmedetomidine, and fentanyl
Role: PI
Chair’s Distinction Funding, Vogt (PI)                                           7/2019 – 6/2022
University of Pittsburgh, Department of Anesthesiology and Perioperative Medicine
Goals: Support additional research costs for junior faculty
Role: PI
Seed Grant, University of Pittsburgh, Department of Anesthesiology; Ibinson (PI)  8/2019 – 6/2022
Title: Neural Correlates of Auriculotherapy
Goals: Demonstrate imaging evidence of changes in chronic low-back pain patients successfully treated with this experimental complementary non-pharmacologic therapy
Role: Co-I
Clinical Research Loan Repayment Program (including competitive renewal)        7/2020 – 6/2022
L30 GM120759, Vogt (PI)
Goals: Financial support for researcher.
Role: PI
Pending Research Support:
Research Project Grant, Oppenheimer (PI)                                       2021 – 2026
R01 MH125825-01A1
Title: Investigation of the Brain and Real-Time Measures of Pain, Affect, and Social Threat in the Development of Suicide Risk in Adolescence
Goals: Determine neural correlates of suicide risk using multi-source behavioral and affective data combined with functional MRI
Role: Co-I
Completed Research Support:
Mentored Research Training Grant, Foundation for Anesthesia Education and Research 7/2017 – 6/2019
Vogt (PI)                                 
Title: Human memory encoding under anesthesia: how pain affects hippocampal and amygdalar contributions to memory
Goals: Determine the degree to which explicit and implicit memories are formed while experiencing pain during minimal sedation with two common anesthetics: midazolam and ketamine 
Role: PI