Ashok Panigrahy, MD

  • Clinical & Translational Imaging Research Professor Department of Radiology Pediatric Radiology Division
  • Vice Chair Department of Radiology

Dr. Panigrahy is Radiologist-in-Chief, Children’s Hospital of Pittsburgh and Vice Chair of Clinical and Translational Imaging Research for the Department of Radiology of the University of Pittsburgh Medical Center (UPMC). Dr. Panigrahy is also a tenured Full Professor and holds the John F. Caffey Endowed Chair of Pediatric Radiology at the University of Pittsburgh with secondary appointments in the Department of Developmental Biology, Biomedical Informatics and Bio-engineering.  He received his undergraduate and medical degrees from Boston University, followed by a fellowship in Radiology at the University of California and a fellowship in Pediatric Neuroradiology at Children’s Hospital Los Angeles. Dr. Panigrahy is presently serving as the Principal Investigator on a multi-center brain connectome R01 grant in collaboration with the NHLBI Pediatric Heart Network, in addition to serving as the Co-Investigator on 6 current NIH grants. He is currently overseeing the neuroimaging harmonization of four current U01 grants with the Pediatric Brain Tumor Consortium, the ADAPT pediatric neurotrauma study, the HEAL (High-Dose Erythropoietin for Asphyxia and Encephalopathy) neonatal brain injury study and the POCCA (Personalizing Outcomes after Child Cardiac Arrest) study. Dr. Panigrahy has published over 175 peer-reviewed manuscripts, reviews and book chapters, and mentored over 30 students and postdocs.

Representative Publications

1. Degnan AJ, Ceschin R, Lee V, Schmithorst VJ, Blüml S, Panigrahy A. Early metabolic development of posteromedial cortex and thalamus in humans analyzed via in vivo quantitative magnetic resonance spectroscopy. J Comp Neurol. 2014 Nov 1;522(16):3717-32.

2. Gertsvolf N, Votava-Smith JK, Ceschin R, Del Castillo S, Lee V, Lai HA, Blüml S, Paquette L, Panigrahy A.  Association between subcortical morphology and cerebral white matter energy metabolism in neonates with congenital heart disease.  Sci Rep 2018 Sep;8(1):14057.  )

3. Panigrahy A, Votava-Smith J, Lee V, Gabriel G, Klena N, Gibbs B, Reynolds WT, Zuccoli G, O'Neil S, Schmithorst VJ, Paquette L, Lo CW. Abnormal brain connectivity and poor neurodevelopmental outcome in congenital heart disease patients with subtle brain dysplasia. Circulation. 2015; 132 (Suppl 3):A16541.

4. Harbison AL, Votava-Smith J, del Castillo S, Kumar SR, Lee V, Schmithorst V, Lai HA, O’Neil S, Blüml S, Paquette L, Panigrahy A.  Clinical factors associated with cerebral metabolism in term neonates with congenital heart disease.  J Pediatr. 2017 Apr;183:67-73.

5. Panigrahy A, Lee V, Cecshin R,  Zuccoli G, Beluk N, Khalifa O, Votava-Smith JK,  DeBrunner M,  Munoz R, Domina Y, Morell V, Wearden P,  Sanchex De Toledo J, Devine W, Zahid,M,  Lo CW.  Brain dysplasia associated with ciliary dysfunction in congenital heart disease infants.  J Pediatr. 2016 Nov;178:141-148.

Research Interests

  • Advanced MR imaging of neonatal brain injury
  • Advanced MR and PET imaging of pediatric brain tumors
  • Pittsburgh Pediatric Device Consortium
  • Fetal MR imaging
  • Advanced MR imaging of non-accidental trauma

Research Grants

Ongoing Research Support

3R34DA050290-01S2                         Panigrahy, Krans & Luna                       09/30/2019 – 03/31/2021

National Institutes of Health/NIDA

Longitudinal Evaluation of the Impact of the COVID-19 Pandemic on High-Risk New and Expectant Mothers

This project builds upon ongoing collaborative research efforts across seven geographically representative sites from the NIH HEALthy Brains and Cognitive Development Study to address this critical gap through collection of longitudinal assessments of COVID-19 related stress, childhood birth and neurobehavioral outcomes, and maternal biological specimens. The result will be both an improved understanding of the consequences of the pandemic on these highly vulnerable populations and the identification of risk and protective factors that provide the foundation for future interventions.

Role:  Co-PI (Krans & Luna)

1RO1 HL152740*                            Panigrahy & Gurvitz                                       03/01/2020 – 02/29/2024

National Institutes of Health/NHLBI

MINDS Neuroimaging Imaging Ancillary Study

This R01 application proposes an ancillary study to the NHLBI-funded Pediatric Heart Network (PHN) “Multi-Institutional Neurocognitive Discovery Study” (MINDS) in Adult Congenital Heart Disease (ACHD). The MINDS-ACHD” study will recruit 500 complex CHD patients between18-30 years old.  We propose to quantitate multi-modal neuroimaging biomarkers (brain injury, structure and physiology) which are not only important components of brain and cognitive reserve but can be predictive of neurocognitive decline and early onset of dementia in the aging non-CHD population. (*Project funded – NOA pending as of May 6, 2020)

Role:  Co-PI (Gurvitz)

1R34 DA050290-01/3R34 DA050290-01S1         Panigrahy, Krans & Luna              09/30/2019 – 03/29/2021

National Institutes of Health/NIDA

Investigation of Opioid Exposure and Neurodevelopment (iOPEN)

The prevalence of opioid use disorder during pregnancy has quadrupled over the past decade. Understanding the complex associations between prenatal opioid use and child neurodevelopment requires carefully coordinated, multidisciplinary efforts and high-level expertise. This collaborative Phase I proposal will set the foundation for a Phase II study to identify protective and resiliency factors that may inform early interventions for pregnant women and young children experiencing a range of adverse exposures.

Role:  Co-PI (Krans & Luna)

3R01 HL128818-05S1                                  Panigrahy (PI)                                   08/01/2019 – 04/30/2021

National Institutes of Health/NHLBI

Hierarchical Bayes Approach to Reduced Inter-Scanner Neuroimaging Variation for CHD and Early Dementia Risk

Role:  PI

5R01 MH115466-02                                 Phillips (PI)                                            07/01/2018 – 06/30/2023

National Institutes of Health/NIMH

Caregiving Effects on the Early Development of Infant Brain-Behavior Relationships

We aim to examine prospective relationships among neural circuitry structure and intrinsic functional connectivity at 3 and 9 months, and change from 3 to 9 months, and: 3-18 month changes in emotional reactivity and regulation.

Role:  Co-Investigator

5R01 EB025032-03                                     Lepore (PI)                                         09/22/2017 – 06/30/2021

National Institutes of Health/NIBIB

Predicting the Early Childhood Outcomes of Preterm Brain Shape Abnormalities

We propose to develop biomarkers of prematurity by statistically comparing the morphological and diffusion properties of subcortical structures between preterm and term neonates using brain MRI. These results will further be used in a sparse learning framework to predict long-term neurodevelopmental outcomes of prematurity.

Role:  Co-Investigator

5R01 MH105538-05                                       Wadhwa (PI)                                      06/19/2015 – 05/31/2020

National Institutes of Health/NIMH

Intergenerational Effects of Maternal Childhood Trauma on the Fetal Brain

Exposure to severe trauma in childhood such as physical or sexual abuse represents one of the most pervasive and pernicious stressors in society.

Role:  Co-Investigator

5R01 HL128818-05                                        Panigrahy (PI)                                   08/01/2015 – 04/30/2021

National Institutes of Health/NHLBI

SVR III:  Brain Connectome and Neurodevelopmental Outcomes

This proposal will address critical gaps in knowledge by relating alterations in brain networks to neurocognitive deficits in Fontan survivors.

Role:  PI

7R01 ES016531-04                           Haynes (Overall PI)                                        09/01/2016 – 08/31/2021

National Institutes of Health/NIEHS

Developmental Effects of Manganese Exposure in Rural Adolescents:  The CARES Cohort Comes of Age

This overarching hypothesis will be addressed through two specific aims. Evaluate neurodevelopment with historic and current biomarkers of Mn in a cohort of rural adolescents to evaluate the impact of Mn .

Role:  Co-Investigator

5U01 NS092764-04                        Wu (Overall PI/Site PI: Yanowitz)            09/30/2016 – 6/30/2021

National Institutes of Health/NINDS

HEAL Study (High-Dose Erythropoietin for Asphyxia and Encephalopathy)

This study aims to study 500 infants ≥ 36 weeks of gestation with moderate or severe HIE will be enrolled across a network of 17 study sites to evaluate the outcomes of 450 (225 in each arm) at 2 years of age. 

Role:  Co-Investigator

W81XWH-16-1-0613                                 Lo & Panigrahy (Co-PIs)                  09/30/2016 – 09/29/2020

Department of Defense

Cilia Dysfunction, Brain Dysplasia, and Poor Neurodevelopmental Outcomes in Congenital Heart Disease

Role:  Co-PI

5R01 NS096714-04                                   Fink (PI)                                              06/01/2016 – 05/31/2021

National Institutes of Health/NINDS

Development of Serum, Imaging, and Clinical Biomarker Driven Models to Direct Clinical Management after Pediatric Cardiac Arrest

Role:  Co-Investigator

5R01 EB024408-02                                           Hetherington (PI)                            09/01/2018 – 05/31/2022

National Institutes of Health/NIBIB

Fast Targeted Spectroscopy Imaging for Brain Tumor Imaging at 3T and 7T

Role:  Co-Investigator