Kang Kim, PhD

  • Associate Professor of Medicine

Dr. Kim directs the Multi-Modality Biomedical Ultrasound Imaging Laboratory (http://www.pitt.edu/~kangkim/) at the Center for Ultrasound Molecular Imaging and Therapeutics (http://www.imagingtherapeutics.pitt.edu/) – home to research focused on basic science, pre-clinical studies and clinical translation of medical instrumentation, signal/image processing algorithms, and imaging contrast/therapeutic agents. He also directs the Small Animal Ultrasonography Core (https://www.vmi.pitt.edu/ultrasonography/index.html) at the Vascular Medicine Institute.

Dr. Kim earned his bachelor’s in educational physics at Seoul National University, his master’s in physics at the University of Pierre & Marie Curie (Paris 6) in Paris, and then his doctorate in acoustics at Pennsylvania State University. After completing his PhD, Dr. Kim became a postdoctoral research fellow and then a member of the research faculty in the Department of Biomedical Engineering at the University of Michigan.

Dr. Kim’s research seeks to develop and translate state-of-the-art noninvasive ultrasound imaging technologies to (1) improve disease diagnosis, (2) guide therapeutic strategies, and (3) evaluate therapeutic efficacy. His research emphasis is on development and application of multi-modality imaging systems that are based on a fundamental understanding of how sound and light interact with soft tissues, and can characterize the structural, mechanical, compositional properties of tissues and organs and their underlying biological activities at the cellular level.

Representative Publications

  1. Sheng Z, Sharma N, Kim K. Ultra-High-Frame-Rate Ultrasound Monitoring of Muscle Contractility Changes Due to Neuromuscular Electrical Stimulation. Ann Biomed Eng. 2020 Jun 1. PubMed PMID: 32483747.
  2. Yu J, Lavery L, Kim K. Super-resolution ultrasound imaging method for microvasculature in vivo with a high temporal accuracy. Sci Rep. 2018 Sep 17;8(1):13918. PubMed PMID: 30224779
  3. Yu J, Chen X, Villanueva FS, Kim K. Vaporization and recondensation dynamics of indocyanine green-loaded perfluoropentane droplets irradiated by a short pulse laser. Appl Phys Lett. 2016;109:243701.
  4. Park DW, Ye SH, Jiang HB, Dutta D, Nonaka K, Wagner WR, Kim K. In vivo monitoring of structural and mechanical changes of tissue scaffolds by multi-modality imaging. Biomaterials. 2014 Sep;35(27):7851-9. PubMed PMID: 24951048
  5. Mahmoud AM, Dutta D, Lavery L, Stephens DN, Villanueva FS, Kim K. Noninvasive detection of lipids in atherosclerotic plaque using ultrasound thermal strain imaging: in vivo animal study. J Am Coll Cardiol. 2013 Nov 5;62(19):1804-9. PubMed PMID: 23916926.

Research Interests

  • ultrasound elasticity imaging (UEI), shear wave imaging (SWI), and acoustic radiation force impulse (ARFI) imaging non-invasively assess the mechanical properties of the tissues and organs
  • ultrasound thermal strain imaging (TSI) strongly contrasts lipids from the surrounding non-lipid tissues
  • super resolution ultrasound imaging (SRU) identifies microvessels at unprecedented high spatial resolution, beyond acoustic diffraction limit of ultrasound
  • photoacoustic molecular imaging (PMI) combines laser and ultrasound technologies to ultrasonically identify optical contrast in deep tissues

Research Grants

Dr. Kim has been PI on eight NIH projects (1R01HL098230, 1R01HL152023, 1R21EB016907, 1R21EB013353, 1R21HL093176, 1R21EB003451, 1S10RR027383, 1S10OD023684), one international collaborative project, and one corporate funded project. He has been Co-PI on two NIH and two NSF projects (NIH P30DK079307, NIH 1R21DK081123, NSF NRI ECCS-1637815, NSF CPS CNS-1646009) and also has served as Co-I for numerous NIH projects.